Critical points in ethylcellulose matrices: Influence of the polymer, drug and filler properties

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Critical points in ethylcellulose matrices: influence of the polymer, drug and filler properties.

Percolation theory has been applied to study the drug release behaviour in multicomponent inert matrices containing ethylcellulose as a matrix forming polymer. Global influence of major formulation factors such as polymer viscosity, polymer particle size, drug and filler solubility and porosity of the tablets in drug release kinetics has been studied for the first time. Batches containing three...

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ژورنال

عنوان ژورنال: Acta Pharmaceutica

سال: 2013

ISSN: 1846-9558,1330-0075

DOI: 10.2478/acph-2013-0005